Description
Skin-R is a Class III CE-marked medical device issued by the National Institute of Health and containing Hyaluronic Acid and Amino Acid Solution at acidic and hyperosmolar pH.
APPLICATION 
Face, neck, décolleté, buttocks, thigh, arm, epigastric area.
FREQUENCY
Aged skin: one session every 15 days, for 4 times. Wait two months, then repeat the cycle 3 times. Very aged skin: one session every 7 days for 4/6 sessions.
Action
Biorestructuring involves activation of the fibrotic fibroblast subpopulation in order to increase dermal stiffness with deposition of scar collagen (type I).
The Medical Device used contains:
Hyaluronic acid fragments (20-30 monomers) capable of activating CD44 in the fibroblast. / An acidic, hypertonic solution capable of inducing an irritative response and stimulating fibrotic fibroblasts. / Collagen precursor amino acids.
Treatment is performed on hypotonic tissues (face, neck, décolleté, buttock, thigh, arm, epigastric area).
Principle of the method
CD44 and CD40 fibroblasts are activated with hyaluronic acid fragments and an acidic, hypertonic solution. Amino acids enable the formation of fibrotic collagen (type I). Fibrosis of the dermis with distension of the skin tissue is achieved.
In general, a biorevitalizer must:
- Perform restructuring and intensely moisturizing action;
- stimulate fibroblasts to produce collagen, elastin, and additional endogenous hyaluronic acid;
- protect fibroblasts from the damaging action of free radicals that are continuously formed, particularly during sun exposure.
Regarding the ability of a biorevitalizing product to stimulate collagen production, it is necessary to distinguish between:
- those that by their composition are able to stimulate the production of reticular collagen (the “good” juvenile type 3 collagen ) and consequently improve the biological functions of the skin through not only reparative, but especially regenerative stimulation(dermal regeneration). In this case, the aim is not solely to improve the skin cosmetically, but to regenerate it, which will then be followed by cosmetic improvement as a second step. In this case it would be better to use the term biostimulation. To activate dermal regeneration, certain substances are used that work by stimulating “fibroblast (dermal cell) receptors, called CD44, to regeneratively produce reticular collagen, hyaluronic acid, and elastin” . An excellent example of this type of biostimulation is autologous biostimulation with PRP, or among synthetic products we can mention Skin B (for young skin),
- Those that by their composition stimulate the production of fibrotic scar collagen (type 1), Skin R type. In this case there will only be a cosmetic effect and not a regenerative one. This type of treatment is carried out on subjects with mature, hypotonic skin in which there is already a considerable presence of fibrotic collagen and in which it becomes virtually impossible to succeed in stimulating the production of youthful (type 3) collagen.
That is why it would be good to start this type of treatment at an age when the skin still has a good capacity to respond to regenerative biostimulation (the one to be preferred).
What is Skin R
It is a biorevitalizer that improves the appearance of sagging skin indicated for hypotonic and photo-damaged mature skin (like mine). With advancing age there is a gradual but continuous loss of collagen, elastin, and hyaluronic acid, resulting in dehydration and the formation of wrinkles. Tissues and skin tend to fail resulting in, by the action of gravity , a downward fall. With Skin R there is an increase in the concentration of fibrotic collagen (type 1), which, with its rigidity and hardness, stretches the skin, retracts it and “pulls” it upward. The effect you will have will be purely aesthetic. In this case, one cannot speak of dermal regeneration because the production of Reticular Collagen (type 3) is not stimulated, except to a small extent.
What skin R contains
- Hyaluronic acid fragments (very fluid) capable of activating fibroblast CD 44 (dermal regeneration, albeit minimal);
- An acidic, hypertonic solution capable of resulting in tissue irritation. Irritants induce an inflammatory reaction in the dermis. The result is the formation of fibrotic collagen, which compacts the skin and, resulting in dermal retraction, implements a stretching of the superficial skin tissue (lifting effect);
- Collagen precursor amino acids. Amino acids enable the formation of fibrotic collagen (type I).
How the biostimulation treatment is carried out
A short, thin needle is used to perform biostimulation, and injections are made into the superficial layer of the dermis. Two different injection techniques can be used:
- the micro-puff technique (an example you can watch in the video). Numerous microinjections are made, very superficial, spaced one centimeter apart in the area you have decided to treat. Pimples remain evident for about a couple of hours, after which the substance distributes evenly in the superficial dermis, drawing water and visibly increasing hydration and skin turgor.
- The linear technique in which multiple, diffuse injections are made into the area to be treated.
