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ALIDYA 5flac340mg+5flac.10ml solvent

AntiCellulite – PostLiposuction

102.00

ALIDYA is a revolutionary new device for the treatment of cellulite.

* Application of the product is reserved only for professional health workers with appropriate qualifications.

MEDICAL DEVICE

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Description

Alidya is the first injectable solution for the treatment of cellulite i.e., injectable solution for specific medical use used with protocol with intradermal therapy with physiological and paraphysiological changes related to the origin and evolution of gynoid lipodystrophy (cellulite). It is developed by Prof. Pasquale Motolese, and patented worldwide. Indications: treatment of gynoid lipodystrophy (cellulite), post-liposuction treatment, post intralipototherapy, lipoedema with or without limphedema, subacute adipose tissue changes.

The Alidya project is carried out with the aim of ensuring nonfunctional but assistive therapy using means to correct changes in skin and subacute tissue structure for lipodystrophy and hypotrophy. Actually, these changes are clinically manifested by the presence of small depressions-negative patches on the surface of the skin, leading to uneven and cracked skin.

Correction of these skin depressions, dents on the surface of the skin is not possible to achieve with existing absorbent fillers available on the market, related to failed attempts with polytactic acid which proved to be very reactive and profibrotic with significant creation of the scared tissue . In reality, it is technically very difficult to make corrections with gelatinous and highly viscous products that release microparticles.

Alidya, with its special formulation is intended for superficial subacute tissues and differs from the rest of the products because it also reacts on deeper parts of the skin such as the dermis. Alydia represents a new class of amino acid-based injectable media equal to those already on the market and used in skin youth (Jalupro, Skinr..) the difference is that Alidya’s formulation is that it is better adapted to the biological environment whether it is a superficial or deeper subacute part of the skin.

Alidya

Alydia is an injection solution for the subacute external part of the skin, which contains components that are rapidly absorbed (within a few hours) that do not contain substances with pharmacological action.

Although there is no other product with the similar specific indication, there are a huge number of products with the similar constitution that are used for the purpose of skin biorevitalization and biorestructuring. The difference between these products and Alidya is that the formulation of Alidya is that it adapts to osmolarity and pH values in different environments not just those within the dermis.

Medical evaluation

Clinical research conducted in women aged 28-65 years showed excellent tolerability of injectable media with no skin reactions of any kind. In addition, the first research (35 women were treated once a week within 7 weeks) showed a high degree of satisfaction among the women surveyed with a desire to repeat the treatment as soon as possible.

Alidya

Alidaya is the first injectable solution for the treatment of cellulite i.e., injectable solution for specific medical use used with protocol with intradermal therapy with physiological and paraphysiological changes related to the origin and evolution of gynoid lipodystrophy (cellulite). It is developed by Prof. Pasquale Motolese, and patented worldwide. Indications: treatment of gynoid lipodystrophy (cellulite), post-liposuction treatment, post intralipototherapy, lipoedema with or without limphedema, subacute adipose tissue changes.

Alidya – eliminates cellulite and brings permanent results

By definition, cellulite is a phenomenon that causes a chain of negative physical and psychological reactions.

The medical name for cellulite is “ADIPOSIS DEMATOSA.”

The development of cellulite is slow and goes in stages:

  • Venous and lymphatic pathway phase: altered microcirculation and small blood vessels are spreading into the deep tissue of the dermis;
  • Edematous phase: the drainage system begins to function more slowly and waste materials are retained within the interstitial space. This causes the fluid to pass through the blood vessels into the tissues, which leads to the development of edema. The interstitial space widens, suppresses content and decreases drainage, creating a charmed circle;
  • Proliferative phase: the irregularities that occur disturb the smooth flow of nutrients and oxygen. Undernourished cells undergo changes in number and size, glycosaminoglycan production enlarges, appears more viscous in texture, and elastic fibers harden forming the reticulum with appearance of shapeless adipocytes collecting in knots on the surface;
  • Phase sclerosis: here there are more palpable nodes, there is reaction and creation of fibrotic scars that pull round formations of dermis causing orange skin i.e., the characteristic appearance of cellulite.

Celulit

ALIDYA composition

  • Polyamino acid gel
  • α 1-4 glycoside
  • EDTA
  • Composition of puffer amino acids in sodium bicarbonate correction, osmolarity regulator
  • D-glucopyranosis: cyclic glucose generates the intermolecular reaction of the alcohol group carbonyl carbon pyranose form glucose.

Effect: amino acid mixture, metal elator, alkalized system connected with extracellular space can be created equilibrium return in the adipose tissue structure.

Usage:

  • Intradermal: mesotherapy or 30G – 4mm needle, at least 7 applications per week, 12 weeks maximum
  • After application put drainage
  • Do not use cosmetics on the application area at least 12 hours after treatment
  • Do not expose it to high heat and/or cold.

Cellulite Treatment – POLICLINIC Tufet

Conversation with Prof. Pasquale Motolese on new hypotheses of cellulite etiogenetics and what we can expect from research in the curative field.

Ginoid lipodystrophy known as cellulite is the most controversial skin problem whose pathophysiological mechanisms and clinical appearance are extremely complex and are not clearly established or fully agreed upon.

Professor Motolese, what is the latest information in the scientific literature?

I don’t think the scientific literature has added anything related to the genesis of cellulite. If we ignore our latest research published in EJAMed on the presence of hemosiderin and ferret ions in the interstitial area of adipose tissue, everything else is bound to support the questionable clinical effect of some apparatus technologies on this deficiency.

What are the best treatments to fight cellulite?

Carbox with effect on arterial microcirculation, old vasotrophic mesotherapy, lymphatic drainage techniques and some others are those for which it is estimated are undoubtedly rational and sometimes not even sufficient to nourish and clinically acceptable. However, they cannot close the charmed circle caused by oxidative damage of cells, which is the real culprit in my opinion, along with the changed biochemical conditions of the interstitial tissue of sclerosis. Then came a new invention called Alidya injection.

What is it?

It is an injection mesotherapy method that is the result of long-standing research and is specifically complex.

What will be the effects?

They are administered through multiple targeted activities of the different components of the injectable media that can be gathered below: solubilization and removal of elements of metallic nature, alkalinization of interstitial matrix (contrast hypoxic acidosis), improvement of cellular oxygenation by relaxation (release) CO2 , Effect of waste and peroxidase shrinkage; induction of matrix restructuring by presence of microstructural amino acid chains according to the appropriate scheme; osmolar balance intra- and extracellular parts.

They spent through the multidirectional action of different components devices for injection as it goes: fusion and removal of metal elements in the subspace of the alkalized matrix (contrast hypoxic acidosis); improves oxygenation of stationery through CO2 scavenging and anti peroxidase effect; induction of restructured matrix by the presence of micro-structured amino acid chains according to certain sequences; osmolar balancing of the intro and out stations of the section.

Studies in Spain have indicated a loss of more centimeters in Alidya treatment areas.

Is it lipolytic effect?

Absolutely not. Some medical conditions are characterized by strong lipedema components whereby the decrease in circumference goes to structural reorganization of the extracellular matrix. It is also possible to hypothesize a uniform arrangement of the cytoarchitectural structure of adipose tissue that results in improved cellular and interstitial physiological function due to improved biochemical and hormonal communication between these two sections. Lipolytic performance, often praised, is never achieved by any substance because the metabolic process can only begin with endogenous hormonal signals (lipolytically dependent intraadipocyte hormone), and thus with metabolic demands. Moreover, known beta receptors in the adipose tissue of reliable regions of the female body are rarely present or completely absent next to alpha1 and alpha2 so that any external signal cannot find their true substrate. However, it is good to keep in mind that the evolution of fibrosclerotic tissue is flanked by tissue atrophy so it is not correct to treat cellulite as excess adipose even though it is certain the increased presence of adipose tissue that should be considered as a risk factor for from the beginning, taking into account the difficulty of steric fiber and the consequent increase in pressure within the tissues.

In my opinion that fulfills the pathophysiology framework that has been missing. Let me explain: the teachings of Curri remain as a foundation, and without it we will certainly not reach these new stages of discoveries. The problem is, in my opinion, conceptual, that is, the microcirculation deficit has always been seen at the beginning and the end of the manifestation in the creation of cellulite. In fact, it is certainly necessary but should be considered an average event. So for a better understanding of the pathogenesis, it should be uniquely identified as a factor causing the microcirculation deficit and well defined as consequences for this. And that is the last aspect where I put my intention.

Can you say that the future brings possibilities of complete and ultimate effectiveness of cellulite treatment?

Under these conditions this leads me to say no. Future research will probably open new horizons and sharpen therapeutic strategies, but it must be considered that gynoid lipodystrophy is a condition for development and that this development leads to unreturnable chemical chisto. Just as Curri said with such an elegant and effective expression naming on the evolution of the phenomenon as “abiotrophic regressive.” Of course, it is a big challenge not to get sclerosis of adipose tissue, and we can do that with Alidya. Another goal is ambitious and almost utopian: to repair the damage already determined. Clearly, if this is achieved someday, therapeutic acts will be of much greater importance in more serious diseases that are now under the aesthetic as we all evidently think.

Some general things about cellulite

Cellulite is a condition that touches a very large population, particularly women 95 percent of the cases as opposed to the remaining 5 percent in men. Over the years of research engaged in combating cellulite, great progress has been made in its treatment. Today, for the solution of this problem we have several solutions available with the tendency to solve the diseases completely and in the long term. The proper term for marking cellulite is PEFS (edematous-fibro-sclerotic panniculopathy) or liposclerosis, and with it the changes that occur in adipose tissue.

There are veins and lymphatic system in these areas. The lymphatic system collects and eliminates waste substances from the body. Between these two systems there may be imbalance between the compositions. This causes the blood flow to slow down and retain fluid within the tissues affecting this entire area. It is cellulite, a series of changes that includes at the same time tissue and connective tissue in some parts of the body. To be more precise i.e., in all respects, one can consider inflammation, which affects the subacute adipose tissue and is manifested by a condition of stagnant fluid that we call edema (swelling). Cellulite in the body changes over time and transforms toward certain stages. The first degree is related to the so-called micro-pathway of lymph and blood or unbalanced outflow of tissue.

These conditions are followed by four defined stages:

  • The phase of decay or stagnation of the venous and lymphatic system, which occurs with hypooxygenation, is then with poor drainage. This condition characterizes the well-known appearance of orange peel that is rough and unpleasant to the touch caused by the increase in adipocytes and subsequent dissociation of elastic fibers that are no longer connected;
  • Infiltrating phase where skin begins to appear more dehydrated and fragile. This stage brings with it the perception of nodules and increased pain to touch;
  • Fibrosis onset phase in which cellulite begins its way to the dermis or deeper layers of the skin. Blockage of carbohydrate elimination, which has been much discussed associated with dieting with weight loss as well as blockage of the lymphatic system, appears at this stage. Aesthetically, the nodules transform into much larger macronodules;
  • Fibrosis scar stage or time when the dermal fiber becomes much denser because the agglomerate is waste, which cannot be eliminated due to the stagnation of fluid such as water and fat. Aesthetically, this phase manifests as swelling on the skin and leads to degenerative changes that can be seen in the early stages. The condition brings with it a strong sensation of pain, which only worsens with the localized, spreading sensation of cold, and originates from the weight affecting the area.

Factors for the occurrence of cellulite

To understand possible solutions for cellulite, it is necessary to understand what makes cellulite look like and what are the main causes of the disease with regard to genetic and lifestyle factors. To understand the causes of cellulite, it is first necessary to see that the triggering reason is not unique but depends on several interrelated factors.

The factors are divided into:

  • Primary those that do not depend on the person’s will or behavior. They refer to gender, race, and genetics. Women generally taken are more prone to cellulite. White women suffer more because they are more susceptible due to estrogen function on specific receptors in their body constitution. The thing to note is the genetic aspect of cellulite because family is the primary cause of the appearance of cellulite. If the mother or grandmother suffers from it, it is very likely that the problem will manifest itself in the next generation of the female population.
  • Secondary is related to the presence of the specific diseases. They are particularly related to the consumption of certain drugs that inhibit proper circulation and contribute to the sedimentation of the fluid layers of the dermis leading to the appearance of the disease. For this factors are related to the application of certain hormones and contraceptive methods such as pills.
  • Aggravating circumstances that relate to lifestyle and for this reason can be corrected. They are particularly related to a wrong and unbalanced diet, weak and inadequate food, and food that is too salty and fatty. Smoking and the consumption of alcoholic beverages leads to the reduction of water retention, which is why they are considered major factors in the formation of cellulite. This was followed by a sedative lifestyle with little exercise while maintaining the same attitude and not being ready for healthier living and more physical activity.

What can we do to get rid of cellulite?

Today, research in aesthetic medicine has provided different weapons to counter this problem. Considering that the causes of cellulite can be numerous and almost always present, it is important that therapy be effective on several fronts. As we have seen above a healthy diet and also light physical activity are necessary to combat cellulite especially in the maintenance phase. Regarding treatments, several complementary techniques are used with usual protocols depending on the patient’s underlying condition. It is clear that because of the diversity of the sample, one type of treatment is usually not efficient.

Today’s usual treatment for cellulite

Mesotherapy is definitely one of the most popular therapeutic acts over the years, and today some people consider it a bit “old” because of the lack of efficiency and commercial promotion of electric treatments with better results and greater comfort for clients. Since October, however, with the appearance on the market of ALIDYA’s new Italian preparation, designed and produced specifically for cellulite, mesotherapy has certainly regained its significance

Virtual mesotherapy, which is like a very efficient weapon. It is the system for transdermal application of cosmetic products, mostly natural-based, but also medicinal, or even more often their combination by specific characterized electricity.

Cavitation, the medical use of low-frequency ultrasound is usually about 40 kHz. It is mainly used for the treatment of localized adiposity because it has the ability to dissolve fat cells and thus reduce the thickness of adipose tissue. The depth of its function is about 2 cm, and this performance of breaking down subcutaneous adipose tissue has a very positive influence on cellulite.

Radiofrequency, acting on specific high-frequency electricity can control act on deep fat cells with biophysical performance of electrical energy into heat. With it a part makes deficiency of existing collagen fibers and skin tightening also encourages the creation of new collagen “neo collagenase” at the same time improves microcirculation. With it, it effectively acts on all three pathophysiological causes of cellulite: it decreases lipocyte volume, improves microcirculation and regenerates connective tissues, and the skin is rejuvenated and firmed.

Lymphatic drainage apparatus, is a massage that enables an important improvement in lymphatic fluid circulation as one of the necessary detoxification procedures. It is also needed for treatments of edema especially in the lower extremities.

Lymphatic clog removal has an extremely positive effect in treating against cellulite and thereby eliminates one of its causes.

 

 

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